Dentrix Enterprise (Henry Schein One) vs Open Dental
Side-by-side from the Top 11 ranking of Best Dental Practice Management Software (2026) | Pricing & Pros Compared. Last verified June 6, 2026.
The short answer
Open Dental ranks higher on Top 11 (#1 vs #7) for Dentists and practice managers. Solo GPs, multi-location groups and DSOs, and specialty practices. the most powerful operatory scheduler in dental, at the lowest price. If you can run your own server.
At a glance
| Dentrix Enterprise (Henry Schein One) | Open Dental | |
|---|---|---|
| Top 11 rank | #7 / Best Dental Practice Management Software (2026) | Pricing & Pros Compared | #1 / Best Dental Practice Management Software (2026) | Pricing & Pros Compared |
| Score (out of 9.4) | 7.9 | 9 |
| Best for | FQHC & large enterprise dental | Complex multi-operatory scheduling |
| Pricing | $$$ (enterprise quote only) | $ ($149 to $199/mo per location + $20/provider over 3) |
| HQ | United States | United States |
| Founded | — | — |
Dentrix Enterprise (Henry Schein One)
Henry Schein's enterprise engine: one central database for unlimited sites, but heavy to implement.
www.dentrixenterprise.com/See full entry in Best Dental Practice Management Software (2026) | Pricing & Pros Compared
Open Dental
the most powerful operatory scheduler in dental, at the lowest price. If you can run your own server.
www.opendental.com/See full entry in Best Dental Practice Management Software (2026) | Pricing & Pros Compared
Methodology and scoring weights live at /methodology. No vendor pays for placement — see about.