Microsoft Defender for Office 365 vs Trend Micro Email and Collaboration Security
Side-by-side from the Top 11 ranking of Top 11 Email Security Software. Last verified July 4, 2026.
The short answer
Microsoft Defender for Office 365 ranks higher on Top 11 (#4 vs #7) for IT and security leaders. Native M365 protection, included in E5 at $0 extra.
At a glance
| Microsoft Defender for Office 365 | Trend Micro Email and Collaboration Security | |
|---|---|---|
| Top 11 rank | #4 / Top 11 Email Security Software | #7 / Top 11 Email Security Software |
| Score (out of 9.4) | 8.8 | 8.4 |
| Best for | Best native option for Microsoft 365 | Best for email plus collaboration apps |
| Pricing | $ ($2/user/mo Plan 1, $5/user/mo Plan 2, or bundled in E5) | $$ (roughly $3 to $6 per user per month) |
| HQ | Redmond, USA | Tokyo, Japan |
| Founded | 2015 | 1988 |
Microsoft Defender for Office 365
Native M365 protection, included in E5 at $0 extra.
www.microsoft.com/en-us/security/business/siem-and-xdr/microsoft-defender-office-365Trend Micro Email and Collaboration Security
API protection across email and collaboration apps.
www.trendmicro.com/en_us/business/products/user-protection/sps/email-and-collaboration.htmlMethodology and scoring weights live at /methodology. No vendor pays for placement — see about.